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2024
Mutations in Tau Protein Promote Aggregation by Favoring Extended Conformations
|
Kevin Pounot, Clara Piersson, Andrew K. Goring, Frédéric Rosu, Valérie Gabelica, Martin Weik, Songi Han,
and Yann Fichou
|
JACS Au 4
92–100
Molecular Crowding: The History and Development of a Scientific Paradigm
|
C Alfano,
Y Fichou
, K Huber, M Weiss, E Spruijt, S Ebbinghaus, ...
|
Chemical Reviews
2023
Mapping Phase Diagram of Tau-RNA LLPS Under Live Cell Coculturing Conditions.
|
Lin Y,
Fichou Y
, Rauch JN, Zhang X, Kosik KS & Han S
|
Protein Aggregation: Methods and Protocols (Cieplak AS, ed)
pp. 269–284. Springer US, New York, NY
Chemical Imaging of RNA-Tau Amyloid Fibrils at the Nanoscale Using Tip-Enhanced Raman Spectroscopy
|
Cooney GS, Talaga D, Ury-Thiery V,
Fichou Y
, Huang Y, Lecomte S & Bonhommeau S
|
Angew Chem Int
Ed 62, e202314369
2022
High-resolution Neutron Spectroscopy to Study Picosecond-nanosecond Dynamics of Proteins and Hydration Water
|
Pounot K, Appel M, Beck C, Weik M, Schirò G,
Fichou Y
, Seydel T & Schreiber F
|
JoVE
63664
Total Internal Reflection Tip-Enhanced Raman Spectroscopy of Tau Fibrils
|
Talaga D, Cooney GS, Ury-Thiery V,
Fichou Y
, Huang Y, Lecomte S & Bonhommeau S
|
J. Phys. Chem. B.
126, 5024–5032
Illuminating the Structural Basis of Tau Aggregation by Intramolecular Distance Tracking: A Perspective on Methods.
|
Zeng Z,
Fichou Y
, Vigers M, Tsay K & Han S
|
J. Phys. Chem. B.
126, 6384–6395
2021
Structures of Pathological and Functional Amyloids and Prions, a Solid-State NMR Perspective
|
Daskalov A., El Mammeri N., Lends, A., Shenoy J., Lamon G.,
Fichou Y.
, Saad A., Martinez D., Morvan E., Berbon M., Grélard A., Kauffmann B., Ferber M., Bardiaux B., Habenstein B., Saupe S. J., Loquet A.
|
Front. Mol. Neurosci.
14
Diffusive-like motions in a solvent free protein-polymer hybrid
|
Schirò G.*#,
FICHOU*# Y.
, Brogan A. P. S., Sessions R., Lohstroh W., Zamponi M., Schneider G. J., Gallat F.-X., Paciaroni A., Tobias D. J., Perriman A., Weik M. #.
|
Phys. Rev. Lett.
126, 088102
Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau.
|
Lin* Y.,
FICHOU* Y.
, Longhini A. P., Llanes L. C., Yin P.; Bazan G. C., Kosik K. S., Han S.
|
J. Mol. Biol.
433 (2), 166731
2020
Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions
|
Lin Y.,
FICHOU Y.
, Zeng Z., Hu N.Y., Han S.
|
ACS Neurosci.
11 (4), 615-627
Mechanisms of heparin-induced tau aggregation revealed by single nanopore
|
Giamblanco* N.,
FICHOU* Y.
, Janot J.-M., Balanzat E., Han S., Balme S.
|
ACS Sensors
5 (4), 1158-1167
2019
Tau-cofactor complexes as building blocks of tau fibrils
|
Fichou Y.
, Oberholtzer Z.R., Ngo H., Cheng C.Y., Keller T.J., Eschmann N.A., Han S.
|
Front. Neurosci.
13
Protein shapes at the core of chronic traumatic encephalopathy
|
Fichou Y.
, Han S
|
Nat. Struct. Mol. Biol.
26, 336–338
The elusive Tau Molecular structures: Can we translate the recent breakthroughs into new targets for intervention?
|
Fichou Y.
, Al-Hilaly Y.K., Devred F., Smet-Nocca C., Tsvetkov P.O., Verelst J., Winderickx J., Geukens N., Vanmechelen E., Perrotin A., Serpell L., Hanseeuw B., Medina M., Buée L., Landrieu L.
|
Neuro Acta Communications
31 (7), 573-575
2018
Cofactors are essential constituents of stable and seeding-active tau fibrils
|
Fichou*# Y.
, Lin* Y., Rauch J., Vigers M., Zeng Z., Srivastava M., Keller T., Freed J., Kosic K., Han# S.
|
Proc. Natl. Acad. Sci.
115(52), 13234–13239
Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer’s disease filaments
|
Fichou Y.
, Vigers M., Goring AK., Eschmann NA., Han S.
|
Chemical Communications
54 (36), 4573-4576
2017
Spatially Heterogeneous Surface Water Diffusivity around Structured Protein Surfaces at Equilibrium
|
Barnes R.,Sun S.,
Fichou Y.
, Dahlquist F., Heyden M., Han S.
|
J. Am. Chem. Soc.
139 (49), 17890–17901
Conformation-based assay of Tau protein aggregation.
|
Fichou Y.
, Eschmann NA., Keller T., Han S.
|
Methods Cell Biol.
141, 89–112
2016
A Ring-Shaped Conduit Connects the Mother Cell and Forespore During Sporulation in Bacillus subtilis
|
Rodrigues C., Henry X., Neumann E., Kurauskas V., Bellard L.,
Fichou Y.
, Schanda P., Schoehn G., Rudner D., Morlot C.
|
Proc. Natl. Acad. Sci.
113, 11585–11590
Mechanisms of Halotolerance: hydration interactions of ectoine with soluble proteins and membranes described by neutron scattering.
|
Zaccai G., Bagyan I., Combet J., Cuello G., Deme B.,
Fichou Y.
, Gallat F.-X., Galvan V., Von Gronau S., Haertlein M., Martel A., Moulin M., Neumann M., Weik M., Oesterhelt D.
|
Sci. Rep.
6, 31434
2015
Molecular Dynamics Simulations of a Powder Model of the Intrinsically Disordered Protein Tau
|
Fichou Y.
, Heyden M., Zaccai G., Weik M., Tobias D.
|
J. Phys. Chem. B,
119, 12580–12589
Translational diffusion of hydration water correlates with functional motions in folded and intrinsically disordered proteins
|
Schirò* G.,
Fichou* Y.
, Gallat* F.-X., Wood K., Gabel F., Moulin M., Härtlein M., Heyden M., Colletier J.-P., Orecchini A., Paciaroni A., Wuttke J., Tobias D.J., Weik M.
|
Nat. Commun.
6, 6490
Hydration water mobility is enhanced around tau amyloid fibers.
|
Fichou# Y.
, Schirò G., Gallat F.-X., Laguri C., Moulin M., Combet J., Zamponi M., Härtlein M., Picart C., Mossou E., Lortat-Jacob H., Colletier J.-P., Tobias# D., Weik# M.
|
Proc. Natl. Acad. Sci.
112, 6365–70
2012
A polymer surfactant corona dynamically replaces water in solvent-free protein liquids and ensures macromolecular flexibility and activity
|
Gallat* F.-X., Brogan* A.P.S.,
Fichou Y.
, McGrath N., Moulin M., Härtlein M., Combet J., Wuttke J., Mann S., Zaccai G., Jackson C.J., Perriman A.W., Weik M
|
J. Am. Chem. Soc.
134, 13168–13171
Analysis of high-frequency modulation response of strongly injection-locked cascaded semiconductor ring lasers
|
Smolyakov G.A.,
Fichou Y.
, Osinski M.
|
IEEE J. Quantum Electron.
48, 1568–1577
2011
Synthesis and characterization of core/shell Fe3O4/ZnSe fluorescent magnetic nanoparticles.
|
Vargas J.M., McBride A.A., Plumley J.B.,
Fichou Y.
, Memon T.A., Shah V., Cook,N.C., Akins B.A., Rivera A.C., Smolyakov G.A., O’Brien J.R., Adolphi, N.L., Smyth H.D.C., Osiński M.
|
J. Appl. Phys.
109, 07B536