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Our research focuses on the molecular mechanisms underlying neurodegenerative diseases. We have a specific interest for the tau protein, an intrinsically disordered protein present in the brain where it regulates the microtubule activity. Tau is directly implicated in several neurodegenerative diseases, including Alzheimer's disease. In these diseases, called tauopathies, tau aggregates into so-called amyloid filaments, which are deleterious for the survival of neurons and can spread throughout the brain following a prion-like mechanism. Our group studies the formation of these aggregates, the factors that determine their structure, their pathological activity as well as their spreading capacity.
We adopt a multi-technique approach in which we use a large array of biochemical and biophysical methods to characterize protein structure, dynamics, thermodynamics and pathogenicity. We have a particular expertise and interest in electron paramagnetic resonance spectroscopy (EPR) applied to protein sciences.
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Laser Game : Fichous Vs. Maisonneuves!
First social event between our two teams sharing the lab space at IECB.
Welcome Victoria
JAfter a PhD in biochemistry and structural biology at the CRPP and Soleil, Victoria joins the group as a research engineer to support different projects in the lab.